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Table 7. Transcripts uniformly elevated in human cancers

Transcripts expressed at 3 copies/cell whose expression is at least 2 fold higher in each cancer compared to its corresponding normal tissue. CC, colon cancer; BC, brain cancer; BrC, breast cancer; LC, lung cancer; M, melanoma; NC, normal colon epithelium; NB, normal brain; NBr, normal breast epithelium; NL, normal lung epithelium; NM, normal melanocytes.  Tag sequence denotes the 10bp tag adjacent to the 4bp NlaIII anchoring enzyme site and Avg T/N is the average ratio of expression in tumor tissue divided by normal tissue (for the purpose of obtaining this ratio, expression values of 0 are converted to 0.5).  UniGene Description provides a description of each matching UniGene cluster (From UniGene Build #67).

 
 

Cancer tissues

Normal Tissues

 

Tag Sequence

CC

BC

BrC

LC

M

NC

NB

NBr

NL

NM

Average T/N

UniGene Description

ATGTGTAACG

93

72

13

5

48

0

0

3

0

0

30

S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin)

CCCTGCCTTG

53

66

120

56

20

21

27

0

8

0

21

Midkine (neurite growth-promoting factor 2)

GTGCGCTGAG

85

103

380

23

58

0

30

56

0

8

18

Major histocompatibility complex, class I, C

CTGGCCGCTC

26

19

53

16

25

3

1

0

0

5

14

Apoptosis inhibitor 4 (survivin)

GCCCCCCCGT

38

40

54

31

29

9

7

3

3

0

12

ESTs

TGGCCCCAGG

13

201

8

24

336

0

30

3

3

19

9

Apolipoprotein CI

CCCTGGTGGG

16

14

17

16

6

0

0

0

0

3

9

ESTs

AGTGACCGAA

5

8

37

8

7

0

1

0

3

0

8

ESTs

CTGCACTTAC

52

34

81

64

78

3

12

22

5

30

8

DNA REPLICATION LICENSING FACTOR CDC47 HOMOLOG

CTGGCGAGCG

168

137

290

73

178

9

21

64

13

60

8

Human ubiquitin carrier protein (E2-EPF) mRNA, complete cds

TTGCCGCTGC

4

10

12

19

7

0

1

0

0

0

7

ESTs

TGCGCTGGCC

22

63

74

28

14

6

18

6

8

0

7

No match

CTCCTGGAAC

20

10

26

18

18

3

4

0

8

5

6

ESTs, Highly similar to MYO-INOSITOL-1-PHOSPHATE SYNTHASE [Arabidopsis thaliana]

CGCCCGTCGT

4

151

30

9

30

0

13

6

0

5

6

No match

TTGCCCCCGT

10

61

15

19

23

0

22

6

5

0

6

AXL receptor tyrosine kinase

TTGCTAAAGG

8

8

16

16

22

3

0

3

8

0

6

ESTs, Weakly similar to KIAA0005 [H.sapiens]

AGCCACGTTG

13

8

11

11

6

0

0

0

0

3

6

Acid phosphatase 1, soluble

CCTGGGCACT

14

6

23

22

8

3

1

3

3

0

6

ESTs, Highly similar to transcription factor ARF6 chain B [M.musculus]

GGGCTCACCT

23

13

52

16

17

3

4

6

3

5

6

Homo sapiens clone 24767 mRNA sequence / ESTs, Weakly similar to colt [D.melanogaster]

CTTACAGCCA

11

6

19

12

6

0

0

3

0

3

6

ESTs

AGGGCCCTCA

14

6

15

5

4

0

3

0

0

0

6

Homo sapiens mRNA, complete cds

GGGTAATGTG

7

13

5

11

12

0

1

0

0

5

5

ESTs, Moderately similar to unknown [M.musculus]

CTGACAGCCC

4

5

17

7

9

0

1

0

0

3

5

Human mRNA for HsMcm6, complete cds

TGACCTCCAG

7

14

15

12

11

0

6

3

3

0

5

ESTs, Weakly similar to No definition line found [C.elegans] / ESTs

AAACCTCTTC

10

5

12

11

8

0

1

3

0

3

5

ESTs, Highly similar to G2/MITOTIC-SPECIFIC CYCLIN B2 [Mesocricetus auratus]

TCATTGCACT

7

13

5

4

9

3

1

0

0

0

5

ESTs, Highly similar to HYPOTHETICAL 16.3 KD PROTEIN [Saccharomyces cerevisiae]

CCCCCTCCGG

31

14

73

38

58

15

3

8

19

11

5

Small nuclear ribonucleoprotein polypeptide N / B and B1

GTAGGGGCCT

11

14

11

19

18

3

6

0

3

8

4

ESTs

GAACCCAAAG

7

8

12

8

10

0

0

3

3

3

4

Plasminogen / PEPTIDYL-PROLYL CIS-TRANS ISOMERASE A

TGTGAGCCTC

5

11

11

7

7

0

3

0

0

3

4

Cyclin F

ATCTCTGGAG

7

3

9

8

7

0

0

0

0

3

4

ESTs

AAAGTGCATC

10

19

11

4

7

0

9

0

0

3

4

No match

GCCTTGGGTG

7

8

4

9

10

3

3

0

0

0

4

Leukemia inhibitory factor (cholinergic differentiation factor)

ACCTCACTCT

9

3

12

16

9

0

0

6

3

3

4

ESTs

TAAAGACTTG

9

13

24

12

38

3

1

11

5

11

4

Adenylate kinase 2 (adk2)

TCGGCGCCGG

15

16

21

14

6

6

3

8

3

0

4

SET translocation (myeloid leukemia-associated)

AACCTCGAGT

6

10

7

8

11

0

4

0

3

3

4

ESTs, Moderately similar to putative [M.musculus]

GTTTACCCGC

6

3

4

7

4

0

0

0

0

0

3

No match

GCCTCTGCCT

4

5

5

5

6

0

0

0

0

3

3

ESTs

CCTGGGTCCT

4

10

8

5

7

0

4

3

0

3

3

ESTs

   

 

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