Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

 

Paul M. Hwang, Fred Bunz, Jian Yu, Carlo Rago, Timothy A. Chan, Michael P. Murphy, Geoffry F. Kelso, Robin A. J. Smith, Kenneth W. Kinzler KW, Bert Vogelstein.

Nature Medicine. 2001 October 7, pp 1111-1117 (2001).

Supplemental Material

Complete list of genes induced or repressed following 5-FU treatment (P-False < 0.05).  WT, number of SAGE tags in p53+/+ HCT116 treated with 5-FU; KO, number of SAGE tags in p53-/- HCT116; WT/KO, fold induction of SAGE tags.  Description indicates SAGE tag match to Unigene ID, with blank space indicating no reliable match.

Tag_Sequence WT KO WT/KO Unigene ID Description
GAGGCCAACA 13 0 13.00 50649 quinone oxidoreductase homolog
GCAACGGGCC 15 0 15.00 8679 cytosolic acyl coenzyme A thioester hydrolase
GGGGCAAAAA 12 0 12.00    
GTGCTCATTC 24 0 24.00 116577 prostate differentiation factor
GTGCTCATTC 24 0 24.00 25945 ESTs
TGGACCCCCC 13 0 13.00 173501 Homo sapiens mRNA for FLJ00008 protein, partial cds
TGGGTGGGGG 18 1 18.00 25197 STIP1 homology and U-Box containing protein 1
GCGGCAGCGG 17 1 17.00 171374 smg GDS-ASSOCIATED PROTEIN
GTGGTGGGCA 17 1 17.00    
TGCCCAGGAT 16 1 16.00 91448 MKP-1 like protein tyrosine phosphatase
GCGGCGGCTC 30 2 15.00 4437 ribosomal protein L28
AGAGAAATTT 14 1 14.00 77028 protein translocation complex beta
AGGGGCGCAG 13 1 13.00 97616 SH3-domain GRB2-like 1
GGGAGGAGGG 13 1 13.00 296370 ESTs
CTGGAAATAA 22 2 11.00 69745 ferredoxin reductase
CTGGAAATAA 22 2 11.00 75576 plasminogen
ACCAAATTAA 19 2 9.50 51233 tumor necrosis factor receptor superfamily, member 10b
ACCCGCCGGG 19 2 9.50    
TGGCGTGGCC 28 3 9.33 8854 Human transcription unit PVT gene, exons I-III
GCGGCTTTCC 17 2 8.50 204354 ras homolog gene family, member B
GCGGCTTTCC 17 2 8.50 278431 SCO (cytochrome oxidase deficient, yeast) homolog 2
GGGTAGCTGG 17 2 8.50 172182 poly(A)-binding protein, cytoplasmic 1
AACCCAGGAG 16 2 8.00    
CTCCACAAAT 24 3 8.00 278426 PDGFA associated protein 1
GGTGCAGAGC 38 5 7.60 183353 ESTs, Weakly similar to
GGTGCAGAGC 38 5 7.60 539 ribosomal protein S29
CAAATAAAAA 20 3 6.67 1116 lymphotoxin beta receptor (TNFR superfamily, member 3
CAAATAAAAA 20 3 6.67 21198 translocase of outer mitochondrial membrane 70 (yeast) homolog A
CAAATAAAAA 20 3 6.67 74034 caveolin 1, caveolae protein, 22kD
GGCAACGTGG 20 3 6.67 80162 Huntingtin interacting protein K
GGCTGGGTTT 20 3 6.67 74870 H2.0 (Drosophila)-like homeo box 1
TGTCCTGGTT 73 11 6.64 179665 cyclin-dependent kinase inhibitor 1A (p21, Cip1)
GGGCGGGGGC 32 5 6.40 165904 ESTs
GGGCGGGGGC 32 5 6.40 300790 ESTs, Highly similar to
GGGCGGGGGC 32 5 6.40 31549 KIAA1501 protein
GGGCGGGGGC 32 5 6.40 99890 polymerase (DNA directed), delta 1, catalytic subunit (125kD)
GTGTTGGGGG 25 4 6.25 55016 hypothetical protein FLJ21935
GGCCCGAGTT 23 4 5.75 179606 nuclear RNA helicase, DECD variant of DEAD box family
GCGAAACCCC 88 18 4.89    
GGCCGCGTTC 47 10 4.70 5174 ribosomal protein S17
GGGAAAAAAA 26 6 4.33 279841 hypothetical protein FLJ10335
GCAAGCCAAC 47 11 4.27    
GTGGCGGGCA 25 6 4.17    
GTGGCGGGCG 83 21 3.95    
GGCTTTAGGG 38 10 3.80    
GCCCCCCCGT 34 9 3.78 228309 EST
GCCCCCCCGT 34 9 3.78 85573 Homo sapiens mRNA; cDNA DKFZp566N034 (from clone DKFZp566N034); partial cds
GGCCCTGAGC 119 32 3.72 71618 polymerase (RNA) II (DNA directed) polypeptide L (7.6kD)
GCGAAACCCT 26 7 3.71    
GGGATGGCAG 37 10 3.70 159637 valyl-tRNA synthetase 2
AGCCCGCCGC 33 9 3.67 154036 tumor suppressing subtransferable candidate 3
GGGACGGGTG 29 8 3.63    
GGGGTAAGAA 38 11 3.45 80423 prostatic binding protein
GTGGCAGGCG 43 13 3.31    
GGGGCAGGGC 49 16 3.06 119140 eukaryotic translation initiation factor 5A
GGGCCCAGGA 33 11 3.00 118983 Homo sapiens cDNA FLJ12150 fis, clone MAMMA1000422
GATCCCAACT 47 16 2.94 118786 metallothionein 2A
GAGAGCTCCC 38 13 2.92 mito Tag matches mitochondrial sequence
CGCCGCGGTG 34 12 2.83 4835 eukaryotic translation initiation factor 3, subunit 8 (110kD)
CCCCCTGGAT 78 28 2.79 275243 S100 calcium-binding protein A6 (calcyclin)
CCCGTCCGGA 307 113 2.72 180842 ribosomal protein L13
AATCTGCGCC 35 13 2.69 833 interferon-stimulated protein, 15 kDa
GCCAGCCCAG 51 20 2.55 228059 KRAB-associated protein 1
GGGGGTCACC 94 37 2.54 80986 ATP synthase, H+ transporting, mitochondrial F0 complex, subunit c (subunit 9), isoform 1
GGCAGAGGAC 104 44 2.36 118638 non-metastatic cells 1, protein (NM23A) expressed in
GGGCCTGTGC 47 20 2.35 146517 ESTs
GGGCCTGTGC 47 20 2.35 85838 solute carrier family 16 (monocarboxylic acid transporters), member 3
GTGAAACCCC 309 136 2.27    
AGCACCTCCA 122 54 2.26 75309 eukaryotic translation elongation factor 2
GCAAAACCCC 51 23 2.22    
GGGCTGGGGT 422 192 2.20 183698 ribosomal protein L29
GCTGTTGCGC 125 57 2.19 8102 ribosomal protein S20
GCAGCCATCC 197 90 2.19 4437 ribosomal protein L28
GGGGTCAGGG 54 25 2.16 133481 Homo sapiens mRNA; cDNA DKFZp564O0862 (from clone DKFZp564O0862)
GGGGTCAGGG 54 25 2.16 75658 phosphorylase, glycogen; brain
GGGGTCAGGG 54 25 2.16 75879 ribosomal protein L19
TTTAACGGCC 80 38 2.11 mito Tag matches mitochondrial sequence
GGGCCCCAAA 62 30 2.07 256301 ESTs
CGCCGCCGGC 314 153 2.05 182825 ribosomal protein L35
GGGAAGCAGA 67 33 2.03    
AGGTGGCAAG 91 45 2.02 mito Tag matches mitochondrial sequence
AACGCGGCCA 123 62 1.98 73798 macrophage migration inhibitory factor (glycosylation-inhibiting factor)
GGCTGGGGGC 187