Angiogenesis Dependent Growth of Colorectal Cancers

Localization of von Willebrand Factor (vWF) in vessels of colorectal cancer using non-radioactive in situ hybridization. Examination of vWF (red stain) revealed a high density of vessels throughout the tumor parenchyma in each of 6 colorectal tumors. At low power magnification (A) vessels were often surrounded by a perivascular cuff of viable cells (red arrows) with a ring of necrotic cells evident at the periphery (black arrows) substantiating the importance of these vessels for tumor growth. At higher power magnification (B) the expression of vWF was clearly localized to the vessels. Sections were counterstained with methyl green. Bar= 100mm.

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