Table 2. Previously characterized and novel Tumor Endothelial Markers (TEMs).

    The top 46 tags with the highest tumor EC (T-EC's) to normal EC (N-EC's) tag ratios are listed in descending order. To calculate tag ratios, a value of 0.5 was assigned in cases where zero tags were observed. The SAGE libraries are the same as those listed in Table 1. Tag numbers for each group were normalized to 100,000 transcripts. A 'Description' of the gene product corresponding to each tag is given, followed by alternative names in parenthesis. †; multiple tags for this gene are due to alternative polyadenylation sites.

no. Tag Sequence N-EC's T-EC's HUVEC HMVEC Cell Lines Description
1 GGGGCTGCCCA 0 28 0 2 0 TEM1
2 GATCTCCGTGT 0 25 0 0 0 TEM2
3 CATTTTTATCT 0 23 0 0 0 TEM3
4 CTTTCTTTGAG 0 22 6 20 1 regulated in glioma-like 7-1 (Dkk-3/ REIC)
5 TATTAACTCTC 0 21 1 3 1 TEM4
6 CAGGAGACCCC 0 16 2 0 0 MMP-11 (stromelysin 3)
7 GGAAATGTCAA 1 31 53 22 1 MMP-2 (gelatinase A, 72kD type IV collagenease)
8 CCTGGTTCAGT 0 15 0 0 0 ESTs
9 TTTTTAAGAAC 0 14 1 4 0 TEM5
10 TTTGGTTTTCC 5 139 0 16 0 collagen, type I, alpha 2, transcript A
11 ATTTTGTATGA 0 13 4 8 0 nidogen (entactin)
12 ACTTTAGATGG 1 23 0 15 0 collagen, type VI, alpha 3
13 GAGTGAGACCC 3 63 0 0 1 Thy-1 cell surface antigen
14 GTACACACACC 0 10 0 0 0 ESTs / cystatin S
15 CCACAGGGGAT 2 38 0 2 1 collagen, type III, alpha 1
16 TTAAAAGTCAC 1 19 1 3 1 TEM6
17 ACAGACTGTTA 4 74 0 0 0 TEM7
18 CCACTGCAACC 1 18 0 1 0  
19 CTATAGGAGAC 1 18 1 1 0 TEM8
20 GTTCCACAGAA 0 9 0 3 0 collagen, type I, alpha 2, transcript B
21 TACCACCTCCC 0 9 4 1 1 ESTs / pregnancy specific beta-1-glycoprotein 1
22 GCCCTTTCTCT 1 17 3 1 2 TEM9 (endo180 lectin)
23 TTAAATAGCAC 2 33 0 4 0 collagen, type I, alpha 1
24 AGACATACTGA 1 16 1 0 0 ESTs, DKFZP434G162 protein
25 TCCCCCAGGAG 1 16 0 0 0 bone morphogenetic protein 1 (metalloprotease)
26 AGCCCAAAGTG 0 8 0 0 0  
27 ACTACCATAAC 0 8 0 0 0 slit (Drosophila) homolog 3 (MEGF5)
28 TACAAATCGTT 0 8 0 0 0 KIAA0672 gene product
29 TTGGGTGAAAA 0 8 0 0 0 ESTs
30 CATTATCCAAA 0 8 0 0 0 integrin, alpha 1
31 AGAAACCACGG 0 8 2 7 0 collagen, type IV, alpha 1
32 ACCAAAACCAC 0 8 0 3 0  
33 TGAAATAAAC 0 8 3 1 1  
34 TTTGGTTTCC 1 15 0 0 0 ESTs
35 GTGGAGACGGA 1 15 1 2 1 ESTs
36 TTTGTGTTGTA 1 14 2 0 0 collagen, typeXII, alpha 1
37 TTATGTTTAAT 3 39 0 0 1 lumican
38 TGGAAATGACC 15 179 0 40 0 ESTs / collagen, type I, alpha 1
39 TGCCACACAGT 1 13 0 2 0 transforming growth factor, beta 3
40 GATGAGGAGAC 3 35 0 18 1 collagen, type I, alpha 2, transcript C
41 ATCAAAGGTTT 2 23 0 0 0 ESTs, DKFZp564O222 mRNA
42 AGTCACATAGT 1 11 2 0 0 ESTs / cell division cycle 42 (GTP-binding protein)
43 TTCGGTTGGTC 4 45 0 19 0  
44 CCCCACACGGG 2 21 0 0 0 ESTs
45 GGCTTGCCTTT 1 10 0 10 1  
46 ATCCCTTCCCG 1 10 1 0 0 peanut-like protein 1
 

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